{"id":789,"date":"2022-05-25T09:21:01","date_gmt":"2022-05-25T09:21:01","guid":{"rendered":"http:\/\/events.marketsandmarkets.com\/blog\/?p=789"},"modified":"2022-05-25T09:21:01","modified_gmt":"2022-05-25T09:21:01","slug":"companion-diagnostics-biomarkers-paving-the-way-for-personalized-medicine","status":"publish","type":"post","link":"https:\/\/events.marketsandmarkets.com\/blog\/companion-diagnostics-biomarkers-paving-the-way-for-personalized-medicine\/","title":{"rendered":"Companion Diagnostics &#038; Biomarkers \u2013 Paving the way for Personalized Medicine"},"content":{"rendered":"\n<p>Prior to and only enhanced by the pandemic, in vitro analysis of biological specimens like tissue samples or blood amongst others plays a huge role in guiding accurate diagnosis &amp; subsequent therapy. When used in tandem with a specific therapeutic drug or medicine and relying on the presence or absence of a predictive biomarker, such IVD are known as <strong>Companion Diagnostics (CDx)<\/strong>. <br> <br>A companion diagnostic is essentially a medical device while helps differentiate patients between responders &amp; non responders with reference to a certain drug or therapy. For example, a \u2018<strong>CDx<\/strong>\u2019 may allow doctors to identify whether a cancer patient\u2019s tumor has had a specific gene change or a reduction when a specific therapy was administered. The test may also showcase lack of efficacy or any potential side effects if that method of treatment continues.<br> <br> Effectively, companion diagnostics help in:<\/p>\n\n\n\n<ul><li>identifying patients who could most likely benefit from a certain kind of therapy\/treatment.<\/li><li>identifying patients who could be adversely affected or stand at risk of life-threatening side effects due to a specific kind of therapeutic product.<\/li><li>monitoring the ongoing response to therapy in order to efficiently alter or adjust the dosage to achieve improved benefit.<\/li><\/ul>\n\n\n\n<p><br>We can clearly understand that purely based off their \u2018<em><strong>modus operandi<\/strong><\/em>\u2019, companion diagnostics are <strong><em>paving the way forward for personalized &amp; precision medicine with specifically targeted therapies, tailored according to an individual\u2019s genetic makeup.<\/em><\/strong><br> <br>A number of benefits exist for the entirety of the healthcare eco-system in adopting, utilizing &amp; pushing forward the use of companion diagnostics. <\/p>\n\n\n\n<ul><li>A better understanding of genetic characteristics and\/or biomarkers of a patient can initiate standard procedures of administering \u2018<em><u>the right drug, at the right dosage for the right person &amp; most importantly at the right time<\/u><\/em>\u2019.<\/li><li>CDx tests allow for early detection and screening of chronic illnesses.<\/li><li>Limit ineffective usage of crucial medical care while optimising patient benefits.<\/li><li>Several entities stand to benefit apart from the patient who stands as the number one priority. Pharmaceutical &amp; diagnostic companies working in collaboration with drug developers to create a therapy linked with a particular CDx shall reap huge profits if the combination is useful &amp; approved.<\/li><li>Reduction is future side effects of drugs on patients who are not suited for a specific form of therapy\/treatment.<\/li><li>Highly touted as the next best thing for oncology, chronic musculoskeletal, cardiovascular, neuropathic and metabolic disorders have also hugely benefited from the ongoing research on CDx and biomarker-based therapies. <\/li><\/ul>\n\n\n\n<p><br>While game-changing technologies &amp; innovations give rise to novel pathways like the use of companion diagnostics, some inherent challenges exist as well.<\/p>\n\n\n\n<ul><li>CDx tests can take up to 5 years to develop at an estimated cost anywhere between $15 to $30 million &amp; the pharmaceutical company must also develop &amp; market the combinational drug simultaneously with the future still hazy at different point in the lifecycle.<\/li><li>A lengthy process which involves several key stages means it takes a toll on those developing these therapies. 6 key stages exist as follows with no guarantee of the an approved or working end product.<ul><li>Scientific validation -&gt; Analytical validation -&gt; Clinical validation -&gt; Demonstration of clinical utility -&gt; Marketing authorization -&gt; Marketing &amp; Post-Commercialization.<\/li><\/ul><\/li><li>Oncology is the main field promoting the growth of biomarker based CDx tests but extremely high costs of cancer immunotherapies could render patients w\/o any options but to resort to other means. CAR T-cell therapies cost well over hundreds of thousands of dollars and switching treatment based od CDx could hamper the progress of the market.<\/li><li>A lack of awareness is omnipresent around the world regarding diagnostics and clinical trials. The eyes of patient &amp; even healthcare professionals must be opened to the potential gains using CDx.<\/li><li>Most importantly, the increasingly stringent regulatory requirements for IVD\u2019s means scientific, clinical &amp; analytical validity will be frequently tested &amp; reconfirmed making it harder to get or maintain the stamp of approval.<\/li><\/ul>\n\n\n\n<p><br>Explore &amp; get up to speed on the future roadmap, trends &amp; challenges within the CDx Industry at the <strong>7th Annual MarketsandMarkets Biomarker and Companion Diagnostics Conference<\/strong> on the <strong>16<sup>th<\/sup>-17<sup>th <\/sup>June 2022<\/strong> at <strong>San Diego, USA<\/strong>.<\/p>\n\n\n\n<p><a href=\"https:\/\/events.marketsandmarkets.com\/7th-annual-marketsandmarkets-biomarker-and-companion-diagnostics-conference\/\"><strong>EXPLORE &amp; REGISTER FOR THE EVENT HERE<\/strong><\/a> or reach out to us at <a href=\"mailto:events@marketsandmarkets.com\"><strong>events@marketsandmarkets.com<\/strong><\/a> regarding any queries you may have.<\/p>\n\n\n\n<p>Ayush Kanitkar<br>MarketsandMarkets<br>+91-8975985061<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prior to and only enhanced by the pandemic, in vitro analysis of biological specimens like tissue samples or blood amongst others plays a huge role in guiding accurate diagnosis &amp; subsequent therapy. When used in tandem with a specific therapeutic drug or medicine and relying on the presence or absence of a predictive biomarker, such IVD are known as Companion Diagnostics (CDx). A companion diagnostic is essentially a medical device while helps differentiate patients between responders &amp; non responders with reference to a certain drug or therapy. For example, a&#8230;<\/p>\n","protected":false},"author":2,"featured_media":793,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,2,4,1],"tags":[17,284,182,282,57,283],"_links":{"self":[{"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/posts\/789"}],"collection":[{"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/comments?post=789"}],"version-history":[{"count":4,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/posts\/789\/revisions"}],"predecessor-version":[{"id":794,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/posts\/789\/revisions\/794"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/media\/793"}],"wp:attachment":[{"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/media?parent=789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/categories?post=789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/events.marketsandmarkets.com\/blog\/wp-json\/wp\/v2\/tags?post=789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}